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4. Madeline Vauthier

After obtaining hanengineering diploma at the ECPM (Ecole européenne de Chimie, Polymères et Matériaux), University of Strasbourg and a M.Sc. degree in Material Sciences from the University of Strasbourg, Madeline Vauthier earned her Ph.D. degree in Material Chemistry (2018) from the University of Haute Alsace (UMR 7361, France) working under the direction of Prof. Vincent Roucoules and Dr. Florence Bally-Le Gall. Her thesis work dealt with the elaboration of functionnal coatings with interfacial thermoreversible properties. She then worked one year (2018-2019) at Institut Charles Sadron as an ATER (temporary assistant professor) in the Precision Macromolecular Chemistry team, where she elaborated biocompatible, biodegradable stimuli-responsive polymeric nanoparticles.

In 2019, she permanently joined the Institut Charles Sadron as an assistant professor, teaching at the chemistry engineering school ECPM, and working on the flow production of smart nano-objects. Her research focuses on the physical-chemistry of polymer materials. Two main themes emerge from her studies:

(i)  The development of stimuli-responsive (nano)materials: She is interested in the functionalization of (bio)polymers or polymer particles to control their physicochemical properties and morphologies (simple spheres, core-shell, Janus, polymersomes, etc.) by modifying the particle environment, such as temperature, UV radiation, or the presence of an electromagnetic field. She also developed a kinetic and thermodynamic methodology to characterize interfacial reactions between (nano)particles of various sizes and surface chemistries. 

(ii)  The encapsulation and release of molecules: Precise control over the physicochemical properties and morphology of nanoparticles is essential for determining and optimizing the drug dose encapsulated within these particles and, thus, the amount subsequently absorbed by the partient's body upon release.

 Targeted applications include but not restricted to sensorics and theranostics.

  

KEYWORDS: Engineering stimuli-responsive polymer objects under flow, polymer physical-chemistry, microfluidic systems, surface engineering, polymersomes, encapsulation

https://www.researchgate.net/profile/Madeline-Vauthier

RESPONSABILITIES: 

USIAS fellow (2023)  https://www.usias.fr/fellows/fellows-2023/madeline-vauthier/

President of Polymer & Materials' chemistry section of the SCF (Société Chimique de France)

Secrétaire Générale Adjointe of the GFP (Groupe Français d'étude et d'Application des Polymères) 

TEAM MEMBERS:

• Emmanuel Olivieri, Ph.D. student, 2025-2028
• Erol Licsandru, ATER, 2024-2026
• Emmanuel Olivieri, M2 student (USIAS Fellowship 2023, ComPoClick), 2025
• Mohamed Boucharba, M2 student, 2025
• Pauline Deschamp, M2 student, 2025
• Itab Youssef, ATER, 2023-2024
• Manissa Saïri, M2 student, 2024
• Vugar Khalilov, Ph.D. student, 2023-2026
• Andrea Acuña, IE (USIAS Fellowship 2023, ComPoClick), 2023-2025
• Charlli Betkou, IE (CNRS pré-maturation ABBA), 2023-2024
• Vugar Khalilov, M2 student, 2023
• Esra Abdioglu, M2 student (INSERM PCSI ITMO cancer OSARM), 2023
  
• Hiba Hussein, IE (CNRS prématuration ABBA), 2022-2023
• Ismayil Safarli, M2 student (ITI HiFunMat project NanoHeatCAPs), 2022
• Javid Abdurahim, Ph.D. student, 2019-2022
• Andrea Acuña, M2 IMPolyS student, 2021
  
• Eirini Skoufa, Ph.D. student (ITN Marie Curie PHOTOEMULSION), 2018-2022

2023

Abdurahim, J.; Serra, C.A.; Vauthier, M. (2023), Elongational-flow elaboration of blend- and Janus-type polymeric nanoparticles,Colloids And Surfaces A-Physicochemical And Engineering Aspects,675() : link

2022

Abdurahim, J.; Serra, C.A.; Blanck, C.; Vauthier, M. (2022), One-step production of highly monodisperse size-controlled poly (lactic-co-glycolic acid) nanoparticles for the release of a hydrophobic model drug,Journal Of Drug Delivery Science And Technology,71() : link

Vauthier, M.; Serra, C.A. (2022), Controlled reversible aggregation of thermoresponsive polymeric nanoparticles by interfacial Diels-Alder reaction,Colloids And Surfaces A-Physicochemical And Engineering Aspects,648() : link

2021

Vauthier, M.; Schmutz, M.; Serra, C.A. (2021), One-step elaboration of Janus polymeric nanoparticles: A comparative study of different emulsification processes,Colloids And Surfaces A-Physicochemical And Engineering Aspects,626() : link

Revol, B.P.; Vauthier, M.; Thomassey, M.; Bouquey, M.; Ruch, F.; Nardin, M. (2021), Design of experience to evaluate the Interfacial compatibility on high tenacity viscose fibers reinforced Polyamide-6 composites,Composites Science And Technology,203() : link

Vauthier, M.; Serra, C.A. (2021), One-step production of polyelectrolyte nanoparticles,Polymer International,70(6, Si) : 860-865 link

2019

Vauthier, M.; Jierry, L.; Mendez, M.L.M.; Durst, Y.-M.; Kelber, J.; Roucoules, V.; Bally-Le Gall, F. (2019), Interfacial Diels-Alder Reaction between Furan-Functionalized Polymer Coatings and Maleimide-Terminated Poly(ethylene glycol),Journal Of Physical Chemistry C,123(7) : 4125-4132 link

Vauthier, M.; Jierry, L.; Oliveira, J.C.; Hassouna, L.; Roucoules, V.; Bally-Le Gall, F. (2019), Interfacial Thermoreversible Chemistry on Functional Coatings: A Focus on the Diels-Alder Reaction,Advanced Functional Materials,29(10) : 1806765 link

2018

Vauthier, M.; Jierry, L.; Boulmedais, F.; Oliveira, J.C.; Clancy, K.F.A.; Simet, C.; Roucoules, V.; Bally-Le Gall, F. (2018), Control of Interfacial Diels-Alder Reactivity by Tuning the Plasma Polymer Properties,Langmuir,34(40) : 11960-11970 link

2015

Diop, M.; Auberval, N.; Viciglio, A.; Langlois, A.; Bietiger, W.; Mura, C.; Peronet, C.; Bekel, A.; David, D.J.; Zhao, M.; Pinget, M.; Jeandidier, N.; Vauthier, C.; Marchioni, E.; Frere, Y.; Sigrist, S. (2015), Design, characterisation, and bioefficiency of insulin-chitosan nanoparticles after stabilisation by freeze-drying or cross-linking,International Journal Of Pharmaceutics,491(1-2) : 402-408 link