Institut Charles Sadron Membre

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4. Delphine Chan-Seng

Delphine Chan-Seng received a B.Sc. degree in chemistry (2000) and a M.Sc. degree in Polymer Sciences (2002) from the University of Bordeaux (France). During her MSc, she spent 5 months working in the Macromolecular Chemistry II laboratory (University of Bayreuth, Germany) on the synthesis of hyperbranched polymers grafted on silica nanoparticles under the supervision of Axel H. E. Müller and Hideharu Mori, and 7 months at the Laboratoire de Chimie des Polymères Organiques (University of Bordeaux, France) under the supervision of Henri Cramail and Eric Cloutet on the synthesis of polyurethane particles in dispersed medium. She earned her Ph.D. degree in Polymer Chemistry (2007) from the University of Toronto (Canada) working under the direction of Michael K. Georges, where her thesis work dealt with controlled radical polymerization focusing on atom transfer radical polymerization under seeded emulsion conditions and the investigation of acrylates polymerization under nitroxide-mediated polymerization conditions. She then conducted postdoctoral research in the group of Todd Emrick at the University of Massachusetts at Amherst, where she focused on the synthesis of polymers for targeted applications, such as the synthesis of aliphatic polyesters and their post-polymerization functionalization used as coatings for drug-elution cardiovascular stents, and the synthesis of peptide-based comb polymers used as non-viral vectors for gene therapy. In 2011, she joined the Institut Charles Sadron as a CNRS researcher.

                                                           ORCID profile                                                             Researchgate profile

CURRENT RESEARCH

We are interested in developing polymers based on synthetic and natural building blocks combining organic chemistry, solid-phase peptide synthesis and polymer chemistry to further modulate the composition, topology and functionality of polymers and thus promote specific intrinsic properties to these polymers. Amino acid- and peptide-based polymers are aimed to find applications in biomedicine (e.g. delivery of small drugs, theranostics, gene therapy, cell adhesion, materials with antimicrobial activities), while the development of novel compatibilizers is targeted for composite materials and polymer blends.

Research interest keywords: polymer synthesis, macromolecular engineering, post-polymerization modification, solid-phase synthesis, polymers for targeted applications

PUBLICATIONS

2022

Razzaq, W.; Serra, C.A.; Jacomine, L.; Chan-Seng, D. (2022), Microfluidic elaboration of polymer microfibers from miscible phases: Effect of operating and material parameters on fiber diameter,Journal of the Taiwan Institute of Chemical Engineers,132() : 104215 link

Razzaq, W.; Serra, C.; Chan-Seng, D. (2022), Production of Janus/Hecate microfibers by microfluidic photopolymerization and evaluation of their potential in dye removal,Chemical Communications,58(29) : 4619-4622 link

Razzaq, W.; Serra, C.A.; Chan-Seng, D. (2022), Microfluidic Janus fibers with dual thermoresponsive behavior for thermoactuation,European Polymer Journal,174() : link

2021

Le Guen, C.; Dussouillez, C.; Kichler, A.; Chan-Seng, D. (2021), Insertion of hydrophobic spacers on dodecalysines as potential transfection enhancers,European Polymer Journal,157() : link

Kavand, A.; Serra, C.A.; Blanck, C.; Lenertz, M.; Anton, N.; Vandamme, T.F.; Mely, Y.; Przybilla, F.; Chan-Seng, D. (2021), Controlled Synthesis of NaYF4:Yb,Er Upconversion Nanocrystals as Potential Probe for Bioimaging: A Focus on Heat Treatment,Acs Applied Nano Materials,4(5) : 5319-5329 link

Louwsma, J.; Carvalho, A.; Lutz, J.-F.; Joly, S.; Chan-Seng, D. (2021), Adsorption of phenylalanine-rich sequence-defined oligomers onto Kevlar fibers for fiber-reinforced polyolefin composite materials,Polymer,217() : link

Figueiredo, M.L.; Letteri, R.; Chan-Seng, D.; Kumar, S.; Rivera-Cruz, C.M.; Emrick, T.S. (2021), Reengineering Tumor Microenvironment with Sequential Interleukin Delivery,Bioengineering-Basel,8(7) : link

2020

Kavand, A.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D. (2020), Synthesis and functionalization of hyperbranched polymers for targeted drug delivery,Journal Of Controlled Release,321() : 285-311 link

Zydziak, N.; Iqbal, M.H.; Chaumont, A.; Combes, A.; Wasielewski, E.; Legros, M.; Jierry, L.; Lavalle, P.; Boulmedais, F.; Chan-Seng, D. (2020), Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains,European Polymer Journal,125() : link

Figueiredo, M.L.; Figueiredo Neto, M.; Salameh, J.W.; Decker, R.E.; Letteri, R.; Chan-Seng, D.; Emrick, T. (2020), Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo,Molecular Therapy-Methods & Clinical Development,17() : 739-751 link

Kavand, A.; Blanck, C.; Przybilla, F.; Mely, Y.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D. (2020), Investigating the growth of hyperbranched polymers by self-condensing vinyl RAFT copolymerization from the surface of upconversion nanoparticles,Polymer Chemistry,11(26) : 4313-4325 link

Ding, S.; Mustafa, B.; Anton, N.; Serra, C.A.; Chan-Seng, D.; Vandamme, T.F. (2020), Production of lipophilic nanogels by spontaneous emulsification,International Journal Of Pharmaceutics,585() : link

Kavand, A.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D. (2020), Tuning polymers grafted on upconversion nanoparticles for the delivery of 5-fluorouracil,European Polymer Journal,137() : link

2018

Chan-Seng, D.; Louwsma, J.; Lutz, J.-F.; Joly, S. (2018), Synthesis of Macromolecules Containing Phenylalanine and Aliphatic Building Blocks,Macromolecular Rapid Communications,39(8) : link

2016

Fiers, G.; Chouikhi, D.; Oswald, L.; Al Ouahabi, A.; Chan-Seng, D.; Charles, L.; Lutz, J.-F. (2016), Orthogonal Synthesis of Xeno Nucleic Acids,Chemistry-A European Journal,22(50) : 17945-17948 link

Ghobadi, A.F.; Letteri, R.; Parelkar, S.S.; Zhao, Y.; Chan-Seng, D.; Emrick, T.; Jayaraman, A. (2016), Dispersing Zwitterions into Comb Polymers for Nonviral Transfection: Experiments and Molecular Simulation,Biomacromolecules,17(2) : 546-557 link

2015

Oswald, L.; Trinh, T.T.; Chan-Seng, D.; Lutz, J.-F. (2015), Debromination of ATRP-made Wang soluble polymer supports,Polymer,72() : 341-347 link

Trinh, T.T.; Oswald, L.; Chan-Seng, D.; Charles, L.; Lutz, J.-F. (2015), Preparation of Information-Containing Macromolecules by Ligation of Dyad-Encoded Oligomers,Chemistry-A European Journal,21(34) : 11961-11965 link

Neto, M.F.; Letteri, R.; Chan-Seng, D.; Emrick, T.; Figueiredo, M.L. (2015), Sonodelivery Facilitates Sustained Luciferase Expression from an Episomal Vector in Skeletal Muscle,Materials,8(7) : 4608-4617 link

2014

Parelkar, S.S.; Letteri, R.; Chan-Seng, D.; Zolochevska, O.; Ellis, J.; Figueiredo, M.; Emrick, T. (2014), Polymer-Peptide Delivery Platforms: Effect of Oligopeptide Orientation on Polymer-Based DNA Delivery,Biomacromolecules,15(4) : 1328-1336 link

Chan-Seng, D.; Lutz, J.-F. (2014), Primary Structure Control of Oligomers Based on Natural and Synthetic Building Blocks,Acs Macro Letters,3(3) : 291-294 link

Trinh, T.T.; Oswald, L.; Chan-Seng, D.; Lutz, J.-F. (2014), Synthesis of Molecularly Encoded Oligomers Using a Chemoselective “ AB plus CD” Iterative Approach,Macromolecular Rapid Communications,35(2, Si) : 141-145 link

2013

Han, D.; Letteri, R.; Chan-Seng, D.; Emrick, T.; Tu, H. (2013), Examination of zwitterionic polymers and gels subjected to mechanical constraints,Polymer,54(12) : 2887-2894 link

2012

Srichan, S.; Chan-Seng, D.; Lutz, J.-F. (2012), Influence of Strong Electron-Donor Monomers in Sequence-Controlled Polymerizations,Acs Macro Letters,1(5) : 589-592 link

Chan-Seng, D.; Zamfir, M.; Lutz, J.-F. (2012), Polymer-Chain Encoding: Synthesis of Highly Complex Monomer Sequence Patterns by Using Automated Protocols,Angewandte Chemie-International Edition,51(49) : 12254-12257 link