Institut Charles Sadron Membre

Aurélie Hourlier-Fargette

  • Téléphone : 03.88.41.40.63
  • Courriel : aurelie.hourlier-fargette@ics-cnrs.unistra.fr
  • CR
  • Bureau : G011
  • Equipe : MIM

At the interface between physics and mechanics, my research interests are focused on elasticity and capillarity. In 2019, I joined the MIM team of ICS, and am developing research activities on foams.

You will find below the following information, in one single webpage:



I - RESEARCH INTERESTS : ELASTICITY, CAPILLARITY & INTERFACES, FROM SOFT MATTER TO MECHANICS


- From liquid to solid foams, beyond capillarity (2020-...)


polyurethane foam

At the interface between physico-chemistry, physics and mechanics, we are developing projects on architectures and properties of foams by studying liquid and solid model systems (simplified foams) and more complex hierarchical composite materials. One example of a model system is presented in the section below.


With more to come!



- Elastic ribbons in 2D foam columns (2020-...)


ribbon in a foam column

Using elastocapillarity to control the architecture of mechanical assemblies have recently highlighted ways to fold, spool, or assemble elastic objects. However, those intelligent design approaches remain unexplored in the context of liquids with a hierarchical architecture, such as foams.

As a first step, we investigated the competition between elasticity and capillarity in a 2D foam column upon introduction of an elastomer ribbon. Confining soap bubbles into a square cross-section container leads to a quasi-2D structure of bubbles, with soap films connected at 120 degrees angles (as prescribed by Plateau's laws). We introduce elastic ribbons of different bending rigidities in the structure and quantify the equilibrium shapes of the foam/ribbon systems, both experimentally (X-ray tomography) and theoretically (energy minimisation under constraints). In addition, our proof-of-concept experiments show that such setup can be used as a method to mold materials with characteristic shapes and curves imprinted by the foam structure. More details can be found in the article we published in Soft Matter in 2022.


One of our pictures of this system has been selected for the final of the CNRS MECAPIXEL photography contest, which goal is to highlight the beauty of mechanical sciences. The vote for the Public prize of this contest is open until March 22nd 2022 on this page.


(with Manon Jouanlanne (PhD student), Antoine Egelé, Damien Favier, Wiebke Drenckhan and Jean Farago)



- Stretchable electronics for vital signs monitoring (2017-2021)


 vital signs monitoring wearable electronics 


Monitoring of vital signs in a clinical setup is usually performed via a collection of hard-wired devices that adhere to the skin, and in certain instances, it involves catheter-based pressure sensors inserted into the arteries. In the most fragile populations, such as in neonatal and pediatric intensive care units, these systems can cause skin injuries and impede natural body movement and skin-to-skin contact with the parents. At Northwestern University and Chicago Lurie Children's hospital, we developed wireless skin-interfaced devices for non invasive physiological monitoring.


More specifically, I worked in John Rogers' group on the modelling of blood pressure and pulse wave velocity (article we published in PNAS in 2018) and on the development of a pair of sensors (one chest sensor and on limb sensor) that conformally adhere to the skin with soft adhesives to monitor health status. Our sensors capture heart rate, blood oxygenation, blood pressure via pulse arrival time techniques, respiratory rate, temperature, but also perform less conventional measurements via the embedded accelerometers, such as the determination of the child position and the capture of cry periods. More details can be found in the article we published in Nature medicine in 2020 (picture above). We also optimized the materials and mechanics, as well as the use of those sensors for blood pressure measurements in the context of neonatal and pediatric intensive care units: see the article we published in Advanced Healthcare Materials in 2021 for additional information.


(with John Rogers' research group)



- Skin-interfaced Microfluidics for in-situ analysis of sweat (2017-2021)


sweat sensing 

Important insights into human health can be obtained through the non-invasive collection and detailed analysis of sweat, a biofluid that contains a wide range of essential biomarkers. In John Rogers' research group, we developed a collection of skin-interfaced soft microfluidics platforms that offer capabilities for in situ capture, storage, and analysis of sweat loss and its constituents. 


Our work focused on in-situ multifunctional colorimetric analysis of sweat (article we published in ACS Sensors), on resistivity measurements for real-time tracking of sweat loss and electrolyte composition (article we published in Small), on integrating enzymatic assays for measuring the concentration of ammonia and ethanol in sweat (article we published in Lab on a Chip), and on coupling colorimetric to digital assessments of a collection of parameters related to stress (article we published in PNAS). We demonstrated that soft skin-interfaced sweat stickers sensors can be used in a clinical setting for cystic fibrosis diagnosis and management (article we published in Science Translational Medicine).


The work I have led more specifically (article we published in Lab on a Chip in 2020) focuses on low-profile skin-interfaced systems that couple disposable microfluidic sampling devices with reusable ‘stick-on’ electrodes and wireless readout electronics that remain isolated from the sweat (featured on the picture above, that was highlighted on the cover of Lab on a Chip journal). Capacitive measurements with different geometries of electrodes allow contactless measurements through a ultrathin microfluidics capping layer, to determine sweat rate and loss and sweat conductivity, which contains information about electrolyte content. Electrodes couple to a flexible, wireless electronics platform that digitizes and transmits information to Bluetooth-enabled devices. On-body field testing during physical exercise validates the performance of the system in scenarios of practical relevance to human health and performance.


(with John Rogers' research group)



- Role of uncrosslinked chains in wetting on silicone elastomers (2014-2018)


  

Beyond the importance of understanding the motion of droplets on stiff surfaces, the recent development of soft materials has lead to a growing interest for capillarity problems where soft interfaces and supports come into play. Silicone elastomers are easy-to-make substrates, used in various research fields such as microfluidics, or elastocapillarity, where experiments on slender bendable structures or thick soft substrates are performed. However, most commercial silicone elastomers are know to contain a small amount of uncrosslinked chains, the effects of which are not completely understood yet.


By focusing on the dynamics of water-glycerol mixture droplets sliding down plates of such silicone elastomers, I highlighted an unexpected behavior: we observed two successive regimes with two different constant speeds, and a sharp transition between them.

We showed that this behavior is due to the water droplet extracting uncrosslinked oligomers from the silicone elastomer through a capillarity-induced phase separation at the triple line.

We deduced from our experimental results and from results from the literature that the second speed regime is reached only when a complete layer of uncrosslinked chains is achieved on the droplet: this study reveals how minute amounts of contaminates have dramatic effects on the wetting dynamics. More details can be found in the article we published in Soft Matter in 2017. We also demonstrated that the contamination occurs at the triple line, and studied its dynamics. For those aspects, more details can be found in the article we published in Langmuir in 2018.


These findings could impact various research domains such as microfluidics or elastocapillarity as it contributes to a better knowledge of the interaction between water and silicone elastomers. Our droplet sliding experiment can also be seen as a simple test to evaluate the presence of unintended free oligomer chains by looking at the dynamics of water droplets on a test surface.


(with Arnaud Antkowiak, Sébastien Neukirch, Antoine Chateauminois and Julien Dervaux)



- Elastocapillarity with thin fibrous membranes (2015-2018)



Elastocapillarity provides a novel strategy to develop highly stretchable materials, taking advantage of spontaneously formed surface reservoirs in wicked thin fibrous membranes. Competition between elasticity and capillarity results in bending of an electrospun nanofibrous liquid-infused membrane. That liquid-solid composite material is a cost-effective, resistant to fatigue highly stretchable mat, promising for applications ranging from conformable chemical surface treatments and stretchable basic electronic circuits.


More details on this project can be found on Paul Grandgeorge's website who was leading this project, and in his PhD thesis!


(with Paul Grandgeorge, Natacha Krins, Christel Laberty-Robert, Arnaud Antkowiak and Sébastien Neukirch)



- Elastocapillary snap-through (2010-2014)




We revisited the well-known snap-through instability from an elastocapillary point of view, showing that capillary forces are able to counterbalance gravity by inducing snap-through with a droplet deposited below a downward buckled elastic strip clamped at both ends. Equilibrium, stability, and dynamics of drop-strip systems were investigated, demonstrating the influence of droplet size and droplet position along the buckled strip, and showing that capillarity is driving the system toward instability but elasticity is ruling the subsequent dynamics. We also designed spin-of versions of the experiment, including a humidity-controlled mechanical switch and upscaled experiments using soap bubbles. More details can be found in the article we published in Physical Review Letters in 2014.


(with Arnaud Antkowiak and Sébastien Neukirch, UPMC)



- Coiling of elastic rods (2011)




As a master intern, I participated in the Coiling Spaghetti project under supervision of Pedro M. Reis at MIT, performing preliminary experiments on the role of natural curvature of a rod on coiling patterns obtained when this rod is deposited onto a moving substrate. By designing home-made rods with customizable natural curvature, we were able to vary this parameter over a large range to test its influence on the patterns, and compare precision desktop-scale experiments to numerical simulations.

This setup can model problems that range from the macroscopic length scale (e.g. the deposition of transoceanic cables) to the microscopic length scale (e.g. coiling of carbon nanotubes). The common ingredient in all these cases is the prominent role of large deformations of a thin elastic rod impacting a rigid boundary.


(with Pedro Reis' research group, MIT)



II- SHORT CV

Work experience

2019-... Permanent researcher (chargée de Recherche CNRS, section 5) at Institut Charles Sadron, Strasbourg, France.

2017-2019 Postdoctoral researcher at Norwestern University, Evanston, USA, under supervision of Pr. John Rogers.

2013-2017 Agrégée préparatrice (PhD thesis + 192h/year teaching) at Ecole Normale Supérieure de Paris (teaching) and Institut Jean Le Rond d Alembert, UPMC, Paris (research)

Awards

2022 Gallery of Soft Matter Award - American Physical Society

2022 Finaliste du concours photo Mécapixel - CNRS INSIS

2018 PhD Prize from the Chancellerie des Universités de Paris - Prix Gandy 2018

2018 Saint-Gobain Young Researcher Prize - Société Française de Physique

Education

2013-2017 PhD thesis, UPMC, Paris, under supervision of Pr. Sébastien Neukirch and Pr. Arnaud Antkowiak. "Soft Interfaces: from elastocapillary snap-through to droplet dynamics on elastomers"

2009-2013 Studies at the Ecole Normale Supérieure de Paris, including:

          2013: Agrégation in Physics

          2012: Masters degree in Fundamental Physics, specialized in Soft Matter Phyics, UPMC, Paris

          2011: 6-month Research internship at MIT, under supervision of Pr. Pedro Reis

          2010: Bachelors degree in Fundamental Physics, Ecole Normale Supérieure de Paris

2007-2009 Classes préparatoires PCSI-PC* (two-year program in Physics, Chemistry and Mathematics)

Engagement in the scientific community

2021-.. Member of the scientific committee of GDR MePhy 

2020-2023 Elected member of the executive board of the French Physical Society (Société Française de Physique)



III - MOST RECENT PUBLICATIONS

full updated list on my google scholar profile, accessible here


2021

Liu, C.; Kim, J.-T.; Kwak, S.S.; Hourlier-Fargette, A.; Avila, R.; Vogl, J.; Tzavelis, A.; Chung, H.U.; Lee, J.Y.; Kim, D.H.; Ryu, D.; Fields, K.B.; Ciatti, J.L.; Li, S.; Irie, M.; Bradley, A.; Shukla, A.; Chavez, J.; Dunne, E.C.; Kim, S.S.; Kim, J.; Park, J.B.; Jo, H.H.; Kim, J.; Johnson, M.C.; Kwak, J.W.; Madhvapathy, S.R.; Xu, S.; Rand, C.M.; Marsillio, L.E.; Hong, S.J.; Huang, Y.; Weese-Mayer, D.E.; Rogers, J.A. (2021), Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring,Advanced Healthcare Materials,10(17, Si) : link

Ray, T.R.; Ivanovic, M.; Curtis, P.M.; Franklin, D.; Guventurk, K.; Jeang, W.J.; Chafetz, J.; Gaertner, H.; Young, G.; Rebollo, S.; Model, J.B.; Lee, S.P.; Ciraldo, J.; Reeder, J.T.; Hourlier-Fargette, A.; Bandodkar, A.J.; Choi, J.; Aranyosi, A.J.; Ghaffari, R.; McColley, S.A.; Haymond, S.; Rogers, J.A. (2021), Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management,Science Translational Medicine,13(587) : link

2020

Kim, S.; Lee, B.; Reeder, J.; Seo, S.H.; Lee, S.-U.; Hourlier-Fargette, A.; Shin, J.; Sekine, Y.; Jeong, H.; Oh, Y.S.; Aranyosi, A.J.; Lee, S.P.; Model, J.B.; Lee, G.; Seo, M.-H.; Kwak, S.S.; Jo, S.; Park, G.; Han, S.; Park, I.; Jung, H.-I.; Ghaffari, R.; Koo, J.; Braun, P.V.; Rogers, J.A. (2020), Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities,Proceedings Of The National Academy Of Sciences Of The United States Of America,117(45) : 27906-27915 link

Kim, S.B.; Koo, J.; Yoon, J.; Hourlier-Fargette, A.; Lee, B.; Chen, S.; Jo, S.; Choi, J.; Oh, Y.S.; Lee, G.; Won, S.M.; Aranyosi, A.J.; Lee, S.P.; Model, J.B.; Braun, P.V.; Ghaffari, R.; Park, C.; Rogers, J.A. (2020), Soft, skin-interfaced microfluidic systems with integrated enzymatic assays for measuring the concentration of ammonia and ethanol in sweat,Lab On A Chip,20(1) : 84-92 link

Hourlier-Fargette, A.; Schon, S.; Xue, Y.; Avila, R.; Li, W.; Gao, Y.; Liu, C.; Kim, S.B.; Raj, M.S.; Fields, K.B.; Parsons, V.B.; Lee, K.H.; Lee, J.Y.; Chung, H.U.; Lee, S.P.; Johnson, M.; Bandodkar, A.J.; Gutruf, P.; Model, J.B.; Aranyosi, A.J.; Choi, J.; Ray, T.R.; Ghaffari, R.; Huang, Y.; Rogers, J.A. (2020), Skin-interfaced soft microfluidic systems with modular and reusable electronics for in situ capacitive sensing of sweat loss, rate and conductivity,Lab On A Chip,20(23) : 4391-4403 link

Liu, C.; Kim, J.-T.; Kwak, S.S.; Hourlier-Fargette, A.; Avila, R.; Vogl, J.; Tzavelis, A.; Chung, H.U.; Lee, J.Y.; Kim, D.H.; Ryu, D.; Fields, K.B.; Ciatti, J.L.; Li, S.; Irie, M.; Bradley, A.; Shukla, A.; Chavez, J.; Dunne, E.C.; Kim, S.S.; Kim, J.; Park, J.B.; Jo, H.H.; Kim, J.; Johnson, M.C.; Kwak, J.W.; Madhvapathy, S.R.; Xu, S.; Rand, C.M.; Marsillio, L.E.; Hong, S.J.; Huang, Y.; Weese-Mayer, D.E.; Rogers, J.A. (), Wireless, Skin-Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring,Advanced Healthcare Materials,() : link