Institut Charles Sadron Membre

Marie-Pierre Krafft

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  • DR
  • Bureau : A266
  • Equipe : SAMS

The general commitment of our group is to identify, understand and exploit the dynamic self-assembling and molecular organizing capacities generated by intense hydrophobic interactions, and hence, those induced by highly fluorinated compounds. Therefore, we conceive, synthesize and investigate nanocompartmented molecular assemblies (interfacial films, surface domains, vesicles, fibers, gels, nanoemulsions, microbubbles, spherulites) with the objective of conceiving new therapeutic agents (lung surfactant substitutes, oxygen carriers, multimodal diagnostic agents, drug delivery systems) and the generation and investigation of self-propelled droplets displaying synchronous collective behavior (active soft matter). The faculty for hydrophobic moieties to disorganize certain structured environments is also being explored. Several studies concern environmental remediation. Industrial collaborations concern uses of fluorinated components in lithium ion batteries, liquid ventilation for therapeutic hypothermia, and theranostic delivery systems.


Nos travaux actuels visent à identifier, comprendre et mettre en Å“uvre les capacités d’auto-assemblage dynamiques et d’organisation moléculaires générées par des interactions fortement hydrophobes, en particulier celles produites par des composés fluorés. S’ensuit, la conception, la synthèse et l’étude d’assemblages moléculaires nano-compartimentés (films interfaciaux organisés, domaines de surface, vésicules, fibres, gels, microbulles, sphérulites), avec comme objectifs des agents thérapeutiques (substituts du surfactant pulmonaire, oxygénation tissulaire, diagnostic, délivrance du médicament), et la génération et l’étude de gouttes auto-propulsées à comportement collectif synchrone (matière molle fluorée active). La capacité des chaines hydrophobes de désorganiser certains milieux structurés est également explorée. Plusieurs études récentes concernent la préservation de l’environnement. Des contrats industriels portent sur l’utilisation de dérivés fluorés pour les batteries lithium ion et la ventilation pulmonaire liquide pour l’hypothermie thérapeutique.

Publications 2018-2020

[158].  Krafft, M. P. Alleviating tumor hypoxia with perfluorocarbon-based oxygen carriers. Curr. Opin. Pharmacol. 2020, in press, 

[157].  Mendoza-Ortega, E. E.; Dubois, M.; Krafft, M. P. Fluorocarbon gas exposure induces disaggregation of nanodiamond clusters and enhanced adsorption, enabling medical microbubble formation. ACS Appl. Nano Mater. 2020,

[156].  Nakahara, H.; Krafft, M. P.; Shibata, O. How self-assembled nanodomains can impact the organization of a phospholipid monolayer. Flower-like arrays. ChemPhysChem 2020, 21: 1-6.

[155].  Mielke, S.; Liu, X.; Krafft, M. P.; Tanaka, M. Influence of semifluorinated alkane surface domains on phase behavior and linear and nonlinear viscoelasticity of phospholipid monolayers. Langmuir 2020, 36: 781-788.

[154].  Nguyen, D.-V.; Hugoni, L.; Filippi, M.; Perton, F.; Shi, D.; Voirin, E.; Power, L.; Cotin, G.; Krafft, M. P.; Scherberich, A.; Lavalle, P.; Begin-Colin, S.; Felder-Flesch, D. Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons. New J. Chem. 2020, 44: 3206-3214.

[153].  Siemer, S.; Wünsch, D.; Khamis, A.; Lu, Q.; Scherberich, A.; Krafft, M. P.; Hagemann, J.; Weiss, C.; Ding, G.-B.; Stauber, R. H.; Gribko, A. Biocompatibility of nanomaterials for translating nanotechnology into medicine: Nano-based applications for early tumor detection. Nanomaterials. 202010, 383.

[152].  Beltran, F.; Vela-Gonzalez, A. V.; Knaub, T.; Schmutz, M.; Krafft, M. P.; Miesch, L. Surfactant micelles enable metal-free spirocyclization of keto-ynamides and access to aza-spiro scaffolds in aqueous media. Eur. J. Org. Chem. 2019: 6989–6993.

[151].  Shi, D.; Nguyen, D.-V.; Maaloum, M.; Gallani, J.-L.; Felder-Flesch, D.; Krafft, M. P. Interfacial behavior of oligo(ethylene glycol) dendrons spread alone and in combination with a phospholipid as Langmuir monolayers at the air/water interface. Molecules 2019, 24: 4114.

[150].  Shi, D.; Wallyn, J.; Nguyen, D.-V.; Perton, F.; Felder-Flesch, D.; Bégin-Colin, S.; Maaloum, M.; Krafft, M. P. Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging. Effective stabilization via fluorous interactions. Beilstein J. Nanotechnol. 201910: 2103-2115.

[149].  Shi, D.; Liu, X.; Counil, C.; Krafft, M. P. Fluorocarbon exposure mode markedly affects phospholipid monolayer behavior at the gas/liquid interface: Impact on size and stability of microbubbles. Langmuir 201935: 10025-10033.

[148].  Nakata, M.; Tanimura, N.; Koyama, D.; Krafft, M. P. Adsorption and desorption of a phospholipid from single microbubbles under pulsed ultrasound irradiation for ultrasound-triggered drug delivery. Langmuir 201935: 10007-10013.

[147]. Tabata, H.; Koyama, D.; Matsukawa, M.; Yoshida, K.; Krafft, M. P. Vibration characteristics and persistence of poloxamer- or phospholipid-coated single microbubbles under ultrasound irradiation. Langmuir 2019, 35: 11322−11329.

[146].  Mielke, S.; Abuillan, W.; Veschgini, M.; Liu, X.; Konovalov, O.; Krafft, M. P.; Tanaka, M. Influence of perfluorohexane-enriched atmosphere on viscoelasticity and structural order of self-assembled semifluorinated alkanes at the air-water Interface. ChemPhysChem 201920: 1698-1705.

[145]. Abbott, N.; Krafft, M. P. A glance into the future of colloid and interface science: What outstanding young researchers tell us. Curr. Opin. Colloid Interface Sci. 2019, 39, A1-A3.

[144].  Workie, Y. A.; Sabrina; Imae, T.; Krafft, M. P. Nitric oxide gas delivery by fluorinated poly(ethylene glycol)@graphene oxide carrier toward pharmacotherapeutics. ACS Biomater. Sci. Eng. 20195: 2926-2934.

[143].  Abuillan, W.; Veschgini, M.; Mielke, S.; Yamamoto, A.; Liu, X.; Konovalov, O.; Krafft, M. P.; Tanaka, M. Long-range lateral correlation between self-assembled domains of fluorocarbon-hydrocarbon tetrablocks by quantitative GISAXS. ChemPhysChem201920: 898-904.

 [142]. Liu, X.-H.; Contal, C.; Schmutz, M.; Krafft, M. P. Two-dimensional radial or ring-banded nonbirefringent spherulites of semifluorinated alkanes coexistent with close-packed self-assembled surface nanodomains. Langmuir 2018, 34: 15126−15133.

[141].  Justeau, C.; Vela-Gonzalez, A. V.; Jourdan, A.; Riess, J. G.; Krafft, M. P. Adsorption of cerium salts and cerium oxide nanoparticles on microbubbles can be induced by a fluorocarbon gas. ACS Sustain. Chem. Eng. 20186: 11450-11456.

[140].  Counil, C.; Krafft, M. P.: When fluorocarbon gases attract molecules and induce their adsorption at interfaces: implications for therapeutic microbubble design and engineering. In Frontiers of Organofluorine Chemistry; Ojima, I., Ed.; World Scientific: Singapore, 2018.

[139].  Liu, X.-H.; Riess, J. G.; Krafft, M. P. Self-organization of semifluorinated alkanes and related compounds at interfaces: thin films, surface domains and two-dimensional spherulites. Bull. Chem. Soc. Jpn. 90th Commemorative Account: Self-organization201891: 846-857.

[138].  Mielke, S.; Habe, T.; Veschgini, M.; Liu, X.-H.; Yoshikawa, K.; Krafft, M. P.; Tanaka, M. Emergence of strong nonlinear viscoelastic response of semifluorinated alkane monolayers. Langmuir 201834: 2489–2496.

[137].  Liu, X.-H.; Mielke, S.; Contal, C.; Favier, D.; Yamamoto, A.; Tanaka, M.; Krafft, M. P. 2D Spherulites of a semi-fluorinated alkane: Controlled access to either radial or ring-banded morphologies. ChemPhysChem 201819: 29-33.

Liste complète des publications ICI


Craig, V.S.J.; Krafft, M.P. (2021), Hot Topic- Nanobubbles and Nanodroplets Nanobubbles and Nanodroplets: from Basics to Applications,Current Opinion In Colloid & Interface Science,55() : link

Krafft, M.P.; Riess, J.G. (2021), 0Therapeutic oxygen delivery by perfluorocarbon-based colloids (vol 294, 102407, 2021),Advances In Colloid And Interface Science,295() : link

Krafft, M.P.; Riess, J.G. (2021), Therapeutic oxygen delivery by perfluorocarbon-based colloids (vol 294, 102407, 2021),Advances In Colloid And Interface Science,294() : link

Krathumkhet, N.; Sabrina; Imae, T.; Krafft, M.P. (2021), Nitric Oxide Gas in Carbon Nanohorn/Fluorinated Dendrimer/Fluorinated Poly(ethylene glycol)-Based Hierarchical Nanocomposites as Therapeutic Nanocarriers,Acs Applied Bio Materials,4(3) : 2591-2600 link

Hagimori, M.; Mendoza-Ortega, E.E.; Krafft, M.P. (2021), Synthesis and physicochemical evaluation of fluorinated lipopeptide precursors of ligands for microbubble targeting,Beilstein Journal Of Organic Chemistry,17() : 511-518 link

Krafft, M.P.; Riess, J.G. (2021), Therapeutic oxygen delivery by perfluorocarbon-based colloids,Advances In Colloid And Interface Science,294() : link

Liu, X.; Counil, C.; Shi, D.; Mendoza-Ortega, E.E.; Vela-Gonzalez, A.V.; Maestro, A.; Campbell, R.A.; Krafft, M.P. (2021), First quantitative assessment of the adsorption of a fluorocarbon gas on phospholipid monolayers at the air/water interface,Journal Of Colloid And Interface Science,593() : 1-10 link


Mendoza-Ortega, E.E.; Dubois, M.; Krafft, M.P. (2020), Fluorocarbon Gas Exposure Induces Disaggregation of Nanodiamond Clusters and Enhanced Adsorption, Enabling Medical Microbubble Formation,Acs Applied Nano Materials,3(9) : 8897-8905 link

Inci, I.; Arni, S.; Iskender, I.; Citak, N.; Rodriguez, J.M.; Weisskopf, M.; Opitz, I.; Weder, W.; Frauenfelder, T.; Krafft, M.P.; Spahn, D.R. (2020), Functional, Metabolic and Morphologic Results of Ex Vivo Donor Lung Perfusion with a Perfluorocarbon-Based Oxygen Carrier Nanoemulsion in a Large Animal Transplantation Model,Cells,9(11) : link

Nguyen, D.-V.; Hugoni, L.; Filippi, M.; Perton, F.; Shi, D.; Voirin, E.; Power, L.; Cotin, G.; Krafft, M.-P.; Scherberich, A.; Lavalle, P.; Begin-Colin, S.; Felder-Flesch, D. (2020), Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons,New Journal Of Chemistry,44(8) : 3206-3214 link

Siemer, S.; Wuensch, D.; Khamis, A.; Lu, Q.; Scherberich, A.; Filippi, M.; KraffT, M.P.; Hagemann, J.; Weiss, C.; Ding, G.-B.; Stauber, R.H.; Gribko, A. (2020), Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy,Nanomaterials,10(2) : link

Nakahara, H.; Krafft, M.P.; Shibata, O. (2020), How Self-Assembled Nanodomains Can Impact the Organization of a Phospholipid Monolayer-Flower-Like Arrays,Chemphyschem,21(17) : 1966-1970 link

Krafft, M.P. (2020), Alleviating tumor hypoxia with perfluorocarbon-based oxygen carriers,Current Opinion In Pharmacology,53(Si) : 117-125 link


Tabata, H.; Koyama, D.; Matsukawa, M.; Yoshida, K.; Krafft, M.P. (2019), Vibration Characteristics and Persistence of Poloxamer- or Phospholipid-Coated Single Microbubbles under Ultrasound Irradiation,Langmuir,35(35) : 11322-11329 link

Nakata, M.; Tanimura, N.; Koyama, D.; Krafft, M.P. (2019), Adsorption and Desorption of a Phospholipid from Single Microbubbles under Pulsed Ultrasound Irradiation for Ultrasound-Triggered Drug Delivery,Langmuir,35(31, Si) : 10007-10013 link

Shi, D.; Liu, X.; Counil, C.; Krafft, M.P. (2019), Fluorocarbon Exposure Mode Markedly Affects Phospholipid Monolayer Behavior at the Gas/Liquid Interface: Impact on Size and Stability of Microbubbles,Langmuir,35(31, Si) : 10025-10033 link

Mielke, S.; Abuillan, W.; Veschgini, M.; Liu, X.; Konovalov, O.; Krafft, M.P.; Tanaka, M. (2019), Influence of Perfluorohexane-Enriched Atmosphere on Viscoelasticity and Structural Order of Self-Assembled Semifluorinated Alkanes at the Air-Water Interface,Chemphyschem,20(13) : 1698-1705 link

Workie, Y.A.; Sabrina; Imae, T.; Krafft, M.P. (2019), Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics,Acs Biomaterials Science & Engineering,5(6) : 2926-2934 link

Abuillan, W.; Veschgini, M.; Mielke, S.; Yamamoto, A.; Liu, X.; Konovalov, O.; Krafft, M.P.; Tanaka, M. (2019), Long-Range Lateral Correlation between Self-Assembled Domains of Fluorocarbon-Hydrocarbon Tetrablocks by Quantitative GISAXS,Chemphyschem,20(6) : 898-904 link

Shi, D.; Nguyen, D.-V.; Maaloum, M.; Gallani, J.-L.; Felder-Flesch, D.; Krafft, M.P. (2019), Interfacial Behavior of Oligo(Ethylene Glycol) Dendrons Spread Alone and in Combination with a Phospholipid as Langmuir Monolayers at the Air/Water Interface,Molecules,24(22) : link

Shi, D.; Wallyn, J.; Nguyen, D.-V.; Perton, F.; Felder-Flesch, D.; Begin-Colin, S.; Maaloum, M.; Krafft, M.P. (2019), Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions,Beilstein Journal Of Nanotechnology,10() : 2103-2115 link

Beltran, F.; Vela-Gonzalez, A.V.; Knaub, T.; Schmutz, M.; Krafft, M.P.; Miesch, L. (2019), Surfactant Micelles Enable Metal-Free Spirocyclization of Keto-Ynamides and Access to Aza-Spiro Scaffolds in Aqueous Media,European Journal Of Organic Chemistry,2019(41) : 6989-6993 link

Abbott, N.; Krafft, M.P. (2019), A glance into the future of colloid and interface science: What outstanding young researchers tell us,Current Opinion In Colloid & Interface Science,39() : 1 link


Liu, X.; Contal, C.; Schmutz, M.; Krafft, M.P. (2018), Two-Dimensional Radial or Ring-Banded Nonbirefringent Spherulites of Semifluorinated Alkanes Coexistent with Close-Packed Self-Assembled Surface Nanodomains,Langmuir,34(50) : 15126-15133 link

Justeau, C.; Vela-Gonzalez, A.V.; Jourdan, A.; Riess, J.G.; Krafft, M.P. (2018), Adsorption of Cerium Salts and Cerium Oxide Nanoparticles on Microbubbles Can Be Induced by a Fluorocarbon Gas,Acs Sustainable Chemistry & Engineering,6(9) : 11450-11456 link

Mielke, S.; Habe, T.; Veschgini, M.; Liu, X.; Yoshikawa, K.; Krafft, M.P.; Tanaka, M. (2018), Emergence of Strong Nonlinear Viscoelastic Response of Semifluorinated Alkane Monolayers,Langmuir,34(7) : 2489-2496 link

Liu, X.; Mielke, S.; Contal, C.; Favier, D.; Yamamoto, A.; Tanaka, M.; Krafft, M.P. (2018), 2D Spherulites of a Semi-Fluorinated Alkane: Controlled Access to Either Radial Or Ring-Banded Morphologies,Chemphyschem,19(1) : 29-33 link

Liu, X.; Riess, J.G.; Krafft, M.P. (2018), Self-Organization of Semifluorinated Alkanes and Related Compounds at Interfaces: Thin Films, Surface Domains and Two-Dimensional Spherulites,Bulletin Of The Chemical Society Of Japan,91(5) : 846-857 link


Veschgini, M.; Abuillan, W.; Inoue, S.; Yamamoto, A.; Mielke, S.; Liu, X.; Konovalov, O.; Krafft, M.P.; Tanaka, M. (2017), Size, Shape, and Lateral Correlation of Highly Uniform, Mesoscopic, Self-Assembled Domains of Fluorocarbon-Hydrocarbon Diblocks at the Air/Water Interface: A GISAXS Study,Chemphyschem,18(19, Si) : 2791-2798 link

Veschgini, M.; Habe, T.; Mielke, S.; Inoue, S.; Liu, X.; Krafft, M.P.; Tanaka, M. (2017), Existence of Two-Dimensional Physical Gels even at Zero Surface Pressure at the Air/Water Interface: Rheology of Self-Assembled Domains of Small Molecules,Angewandte Chemie-International Edition,56(41) : 12603-12607 link

Schwieger, C.; Liu, X.; Krafft, M.P. (2017), Self-assembled mesoscopic surface domains of fluorocarbon-hydrocarbon diblocks can form at zero surface pressure: tilting of solid-like hydrocarbon moieties compensates for cross-section mismatch with fluorocarbon moieties,Physical Chemistry Chemical Physics,19(35) : 23809-23816 link

Fisicaro, E.; Compari, C.; Bacciottini, F.; Contardi, L.; Pongiluppi, E.; Barbero, N.; Viscardi, G.; Quagliotto, P.; Donofrio, G.; Krafft, M.P. (2017), Nonviral gene-delivery by highly fluorinated gemini bispyridinium surfactant-based DNA nanoparticles,Journal Of Colloid And Interface Science,487() : 182-191 link


Ando, Y.; Tabata, H.; Sanchez, M.; Cagna, A.; Koyama, D.; Krafft, M.P. (2016), Microbubbles with a Self-Assembled Poloxamer Shell and a Fluorocarbon Inner Gas,Langmuir,32(47, Si) : 12461-12467 link

Gazzera, L.; Milani, R.; Pirrie, L.; Schmutz, M.; Blanck, C.; Resnati, G.; Metrangolo, P.; Krafft, M.P. (2016), Design of Highly Stable Echogenic Microbubbles through Controlled Assembly of Their Hydrophobin Shell,Angewandte Chemie-International Edition,55(35) : 10263-10267 link

Kovalenko, A.; Jouhannaud, J.; Polavarapu, P.; Krafft, M.P.; Waton, G.; Pourroy, G. (2016), Incorporation of negatively charged iron oxide nanoparticles in the shell of anionic surfactant-stabilized microbubbles: The effect of NaCl concentration,Journal Of Colloid And Interface Science,472() : 180-186 link

Ma, J.; Pourroy, G.; Krafft, M.P. (2016), Stable Small Composite Microbubbles Decorated with Magnetite Nanoparticles - A Synergistic Effect between Surfactant Molecules and Nanoparticles,Journal Of Oleo Science,65(5) : 369-376 link


Krafft, M.P.; Fainerman, V.B.; Miller, R. (2015), Modeling of the effect of fluorocarbon gases on the properties of phospholipid monolayers and the adsorption dynamics of their aqueous solutions or dispersions,Colloid And Polymer Science,293(11, Si) : 3091-3097 link

Mys, V.D.; Fainerman, V.B.; Makievski, A.V.; Krafft, M.P.; Miller, R. (2015), Dynamic surface tension of C10EO8 at the aqueous solution/hexane vapor interface as measured by bubble pressure tensiometry,Colloids And Surfaces A-Physicochemical And Engineering Aspects,483() : 137-141 link

Yang, G.; ODuill, M.; Gouverneur, V.; Krafft, M.P. (2015), Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas,Angewandte Chemie-International Edition,54(29) : 8402-8406 link

Krafft, M.P.; Riess, J.G. (2015), Selected physicochemical aspects of poly- and perfluoroalkylated substances relevant to performance, environment and sustainability-Part one,Chemosphere,129(Si) : 4-19 link

Yamamoto, D.; Nakajima, C.; Shioi, A.; Krafft, M.P.; Yoshikawa, K. (2015), The evolution of spatial ordering of oil drops fast spreading on a water surface,Nature Communications,6() : link

Polavarapu, P.; Krafft, M.P. (2015), Perfluoroalkylated poly(oxyethylene) thiols: Synthesis, adsorption dynamics and surface activity at the air/water interface, and bubble stabilization behaviour,Journal Of Fluorine Chemistry,171(Si) : 12-17 link


Krafft, M.P. (2014), Perfluoroalkyl chains as tools for film surface nano-patterning and soft microbubble engineering and decoration,Journal Of The Taiwan Institute Of Chemical Engineers,45(6) : 3069-3074 link

Ponzio, F.; Payamyar, P.; Schneider, A.; Winterhalter, M.; Bour, J.; Addiego, F.; Krafft, M.-P.; Hemmerle, J.; Ball, V. (2014), Polydopamine Films from the Forgotten Air/Water Interface,Journal Of Physical Chemistry Letters,5(19) : 3436-3440 link

Kovalenko, A.; Polavarapu, P.; Gallani, J.-L.; Pourroy, G.; Waton, G.; Krafft, M.P. (2014), Super-Elastic Air/Water Interfacial Films Self-Assembled from Soluble Surfactants,Chemphyschem,15(12) : 2440-2444 link

Kovalenko, A.; Polavarapu, P.; Pourroy, G.; Waton, G.; Krafft, M.P. (2014), pH-Controlled Microbubble Shell Formation and Stabilization,Langmuir,30(22) : 6339-6347 link

Jacoby, C.; Temme, S.; Mayenfels, F.; Benoit, N.; Krafft, M.P.; Schubert, R.; Schrader, J.; Floegel, U. (2014), Probing different perfluorocarbons for in vivo inflammation imaging by F-19 MRI: image reconstruction, biological half-lives and sensitivity,Nmr In Biomedicine,27(3) : 261-271 link

Nguyen, P.N.; Veschgini, M.; Tanaka, M.; Waton, G.; Vandammec, T.; Krafft, M.P. (2014), Counteracting the inhibitory effect of proteins towards lung surfactant substitutes: a fluorocarbon gas helps displace albumin at the air/water interface,Chemical Communications,50(78) : 11576-11579 link

Kovalenko, A.; Jouhannaud, J.; Polavarapu, P.; Krafft, M.P.; Waton, G.; Pourroy, G. (2014), Hollow magnetic microspheres obtained by nanoparticle adsorption on surfactant stabilized microbubbles,Soft Matter,10(28) : 5147-5156 link


Lux, C. de G.; Donnio, B.; Heinrich, B.; Krafft, M.P. (2013), Thermal Behavior and High- and Low-Temperature Phase Structures of Gemini Fluorocarbon/Hydrocarbon Diblocks,Langmuir,29(17) : 5325-5336 link

Nguyen, P.N.; Waton, G.; Vandamme, T.; Krafft, M.P. (2013), Reversing the course of the competitive adsorption between a phospholipid and albumin at an air-water interface,Soft Matter,9(42) : 9972-9976 link

Nguyen, P.N.; Waton, G.; Vandamme, T.; Krafft, M.P. (2013), Behavior of an Adsorbed Phospholipid Monolayer Submitted to Prolonged Periodical Surface Density Variations,Angewandte Chemie-International Edition,52(25) : 6404-6408 link

Nguyen, P.N.; Nikolova, G.; Polavarapu, P.; Waton, G.; Phuoc, L.T.; Pourroy, G.; Krafft, M.P. (2013), Compressible multi-scale magnetic constructs: decorating the outer surface of self-assembled microbubbles with iron oxide nanoparticles,Rsc Advances,3(21) : 7743-7746 link


Giulieri, F.; Jeanneaux, F.; Goldmann, M.; Krafft, M.P. (2012), Impact of the Spacer on the Condensing Effect of Fluorinated Chains Investigated by Grazing Incidence X-ray Diffraction on Ultrathin Langmuir Monolayers,Langmuir,28(33) : 12022-12029 link

Lux, C. de G.; Gallani, J.-L.; Waton, G.; Krafft, M.P. (2012), Stacking of Self-Assembled Surface Micelles in Ultrathin Films,Chemphyschem,13(6) : 1454-1462 link

Krafft, M.P. (2012), Strasbourg’s SOFFT team-Soft functional systems self-assembled from perfluoroalkylated molecular components,Journal Of Fluorine Chemistry,134(Si) : 90-102 link

Szijjarto, C.; Rossi, S.; Waton, G.; Krafft, M.P. (2012), Effects of Perfluorocarbon Gases on the Size and Stability Characteristics of Phospholipid-Coated Microbubbles: Osmotic Effect versus Interfacial Film Stabilization,Langmuir,28(2) : 1182-1189 link

Maillard, E.; Juszczak, M.T.; Langlois, A.; Kleiss, C.; Sencier, M.C.; Bietiger, W.; Sanchez-Dominguez, M.; Krafft, M.P.; Johnson, P.R.V.; Pinget, M.; Sigrist, S. (2012), Perfluorocarbon Emulsions Prevent Hypoxia of Pancreatic beta-Cells,Cell Transplantation,21(4) : 657-669 link


Rossi, S.; Szijjarto, C.; Gerber, F.; Waton, G.; Krafft, M.P. (2011), Fluorous materials in microbubble engineering science and technology-Design and development of new bubble preparation and sizing technologies,Journal Of Fluorine Chemistry,132(12, Si) : 1102-1109 link

Bardin, L.; Faure, M.-C.; Lirnagne, D.; Chevallard, C.; Konovalov, O.; Filipe, E.J.M.; Waton, G.; Krafft, M.P.; Goldmann, M.; Fontaine, P. (2011), Long-Range Nanometer-Scale Organization of Semifluorinated Alkane Monolayers at the Air/Water Interface,Langmuir,27(22) : 13497-13505 link

Nguyen, P.N.; Dang, T.T.T.; Waton, G.; Vandamme, T.; Krafft, M.P. (2011), A Nonpolar, Nonamphiphilic Molecule Can Accelerate Adsorption of Phospholipids and Lower Their Surface Tension at the Air/Water Interface,Chemphyschem,12(14) : 2646-2652 link

Goldmann, M.; Krafft, M.P. (2011), Semi-fluorinated alkanes in surface water,Actualite Chimique,(356-57) : 84-87 link

Tewes, F.; Krafft, M.P.; Boury, F. (2011), Dynamical and Rheological Properties of Fluorinated Surfactant Films Adsorbed at the Pressurized CO2-H2O Interface,Langmuir,27(13) : 8144-8152 link


Nakahara, H.; Lee, S.; Krafft, M.P.; Shibata, O. (2010), Fluorocarbon-Hybrid Pulmonary Surfactants for Replacement Therapy - A Langmuir Mono layer Study,Langmuir,26(23) : 18256-18265 link

Rossi, S.; Waton, G.; Krafft, M.P. (2010), Phospholipid-Coated Gas Bubble Engineering: Key Parameters for Size and Stability Control, as Determined by an Acoustical Method,Langmuir,26(3) : 1649-1655 link

Lux, C. de G.; Gallani, J.-L.; Waton, G.; Krafft, M.P. (2010), Compression of Self-Assembled Nano-Objects: 2D/3D Transitions in Films of (Perfluoroalkyl)Alkanes-Persistence of an Organized Array of Surface Micelles,Chemistry-A European Journal,16(24) : 7186-7198 link

Lux, C. de G.; Krafft, M.P. (2010), Nonpolar Gemini Amphiphiles Self-Assemble into Stacked Layers of Nano-Objects,Chemistry-A European Journal,16(38) : 11539-11542 link


Maillard, E.; Sencier, M.C.; Langlois, A.; Bietiger, W.; Krafft, M.P.; Pinget, M.; Sigrist, S. (2009), Extracellular matrix proteins involved in pseudoislets formation,Islets,1(3) : 232-241 link

Nakahara, H.; Tsuji, M.; Sato, Y.; Krafft, M.P.; Shibata, O. (2009), Langmuir monolayer miscibility of single-chain partially fluorinated amphiphiles with tetradecanoic acid,Journal Of Colloid And Interface Science,337(1) : 201-210 link

Haiss, F.; Jolivet, R.; Wyss, M.T.; Reichold, J.; Braham, N.B.; Scheffold, F.; Krafft, M.P.; Weber, B. (2009), Improved in vivo two-photon imaging after blood replacement by perfluorocarbon,Journal Of Physiology-London,587(13) : 3153-3158 link

Gerber, F.; Vandamme, T.R.; Krafft, M.P. (2009), Impact of perfluorooctylethane on the formation of a semi-crystalline liquid-condensed phase in a phospholipid monolayer and of perfluorooctyl bromide on the adsorption of albumin on such a monolayer,Comptes Rendus Chimie,12(1-2) : 180-187 link


Rossi, S.; Waton, G.; Krafft, M.P. (2008), Small phospholipid-coated gas bubbles can last longer than larger ones,Chemphyschem,9(14) : 1982-1985 link


Nakamura, S.; Nakahara, H.; Krafft, M.P.; Shibata, O. (2007), Two-component Langmuir monolayers of single-chain partially fluorinated amphiphiles with dipalmitoylphosphatidylcholine (DPPC),Langmuir,23(25) : 12634-12644 link

Krafft, M.P.; Riess, J.G. (2007), Perfluorocarbons: Life sciences and biomedical uses - Dedicated to the memory of Professor Guy Ourisson, a true RENAISSANCE man,Journal Of Polymer Science Part A-Polymer Chemistry,45(7) : 1185-1198 link

Gerber, F.; Krafft, M.P.; Vandamme, T.F. (2007), The detrimental effect of serum albumin on the re-spreading of a dipalmitoyl phosphatidylcholine Langmuir monolayer is counteracted by a fluorocarbon gas,Biochimica Et Biophysica Acta-Biomembranes,1768(3) : 490-494 link

Gonzalez-Perez, A.; Schmutz, M.; Waton, G.; Romero, M.J.; Krafft, M.P. (2007), Isolated fluid polyhedral vesicles,Journal Of The American Chemical Society,129(4) : 756-757 link

Gerber, F.; Waton, G.; Krafft, M.P.; Vandamme, T.F. (2007), Long lived microbubbles for oxygen delivery,Artificial Cells Blood Substitutes And Biotechnology,35(1, Si) : 119-124 link

Gerber, F.; Krafft, M.P.; Vandamme, T.F.; Goldmann, M.; Fontaine, P. (2007), Potential use of fluorocarbons in lung surfactant therapy,Artificial Cells Blood Substitutes And Biotechnology,35(2) : 211-220 link

Gonzalez-Perez, A.; Contal, C.; Krafft, M.P. (2007), Experimental evidence for a surface concentration-dependent mechanism of formation of hemimicelles in Langmuir monolayers of semi-fluorinated alkanes,Soft Matter,3(2) : 191-193 link


Jouan-Hureaux, V.; Audonnet-Blaise, S.; Lacatusu, D.; Krafft, M.-P.; Dewachter, P.; Cauchois, G.; Stoltz, J.-F.; Longrois, D.; Menu, P. (2006), Effects of a new perfluorocarbon emulsion on human plasma and whole-blood viscosity in the presence of albumin, hydroxyethyl starch, or modified fluid gelatin: an in vitro rheologic approach,Transfusion,46(11) : 1892-1898 link

Semenov, A.N.; Gonzalez-Perez, A.; Krafft, M.P.; Legrand, J.-F. (2006), Theory of surface micelles of semifluorinated alkanes,Langmuir,22(21) : 8703-8717 link

Krafft, M.P.; Riess, J.G. (2006), Highly fluorinated components and colloids for diagnosis and therapy,Actualite Chimique,(301-302) : 88-92 link

Dominguez, M.S.; Maillard, E.; Krafft, M.P.; Sigrist, S.; Belcourt, A. (2006), Prevention of adhesion and promotion of pseudoislets formation from a beta-cell line by fluorocarbon emulsions,Chembiochem,7(8) : 1160-1163 link

Krafft, M.P. (2006), Highly fluorinated compounds induce phase separation in, and nanostructuration of liquid media. Possible impact on, and use in chemical reactivity control,Journal Of Polymer Science Part A-Polymer Chemistry,44(14) : 4251-4258 link

Audonnet-Blaise, S.; Krafft, M.-P.; Smani, Y.; Mertes, P.-M.; Marie, P.-Y.; Labrude, P.; Longrois, D.; Menu, P. (2006), Resuscitation of severe but brief haemorrhagic shock with PFC in rabbits restores skeletal muscle oxygen delivery and does not alter skeletal muscle. metabolism,Resuscitation,70(1) : 124-132 link

Gerber, F.; Krafft, M.P.; Vandamme, T.F.; Goldmann, M.; Fontaine, P. (2006), Fluidization of a dipalmitoyl phosphatidylcholine monolayer by fluorocarbon gases: Potential use in lung surfactant therapy,Biophysical Journal,90(9) : 3184-3192 link

Gerber, F.; Krafft, M.P.; Waton, G.; Vandamme, T.F. (2006), Microbubbles with exceptionally long life - synergy between shell and internal phase components,New Journal Of Chemistry,30(4) : 524-527 link


Zhang, G.F.; Marie, P.; Maalourn, M.; Muller, P.; Benoit, N.; Krafft, M.P. (2005), Occurrence, shape, and dimensions of large surface hemimicelles made of semifluorinated alkanes. elongated versus circular hemimicelles. Pit- and tip-centered hemimicelles,Journal Of The American Chemical Society,127(29) : 10412-10419 link

Riess, J.G.; Krafft, M.P. (2005), Improving diagnosis efficacy with perfluorocarbons,Chimica Oggi-Chemistry Today,23(3) : link

Fontaine, P.; Goldmann, M.; Muller, P.; Faure, M.C.; Konovalov, O.; Krafft, M.P. (2005), Direct evidence for highly organized networks of circular surface micelles of surfactant at the air-water interface,Journal Of The American Chemical Society,127(2) : 512-513 link

Gerber, F.; Krafft, M.P.; Vandamme, T.F.; Goldmann, M.; Fontaine, P. (2005), Preventing crystallization of phospholipids in monolayers: A new approach to lung-surfactant therapy,Angewandte Chemie-International Edition,44(18) : 2749-2752 link


Benattar, J.J.; Shen, Q.; Bratskaya, S.; Petkova, V.; Krafft, M.P.; Pucci, B. (2004), Modification of black film hydration by infrared irradiation,Langmuir,20(4) : 1047-1050 link

Maaloum, M.; Muller, P.; Krafft, M.P. (2004), Lateral and vertical nanophase separation in Langmuir-Blodgett films of phospholipids and semifluorinated alkanes,Langmuir,20(6) : 2261-2264 link

Zhang, G.F.; Maaloum, M.; Muller, P.; Benoit, N.; Krafft, M.P. (2004), Surface micelles of semifluorinated alkanes in Langmuir-Blodgett monolayers,Physical Chemistry Chemical Physics,6(7) : 1566-1569 link

Bertilla, S.M.; Thomas, J.L.; Marie, P.; Krafft, M.P. (2004), Cosurfactant effect of a semifluorinated alkane at a fluorocarbon/water interface: Impact on the stabilization of fluorocarbon-in-water emulsions,Langmuir,20(10) : 3920-3924 link

Courrier, H.M.; Pons, F.; Lessinger, J.M.; Frossard, N.; Krafft, M.P.; Vandamme, T.F. (2004), In vivo evaluation of a reverse water-in-fluorocarbon emulsion stabilized with a semifluorinated amphiphile as a drug delivery system through the pulmonary route,International Journal Of Pharmaceutics,282(1-2) : 131-140 link

Courrier, H.A.; Vandamme, T.F.; Krafft, M.P. (2004), Reverse water-in-fluorocarbon emulsions and microemulsions obtained with a fluorinated surfactant,Colloids And Surfaces A-Physicochemical And Engineering Aspects,244(1-3) : 141-148 link


Hiranita, T.; Nakamura, S.; Kawachi, M.; Courrier, H.N.; Vandamme, T.F.; Krafft, M.P.; Shibata, O. (2003), Miscibility behavior of dipalmitoylphosphatidylcholine with a single-chain partially fluorinated amphiphile in Langmuir monolayers,Journal Of Colloid And Interface Science,265(1) : 83-92 link

Krafft, M.P.; Goldmann, M. (2003), Monolayers made from fluorinated amphiphiles,Current Opinion In Colloid & Interface Science,8(3) : 243-250 link

Krafft, M.P.; Chittofrati, A.; Riess, J.G. (2003), Emulsions and microemulsions with a fluorocarbon phase,Current Opinion In Colloid & Interface Science,8(3) : 251-258 link

Schmutz, M.; Michels, B.; Marie, P.; Krafft, M.P. (2003), Fluorinated vesicles made from combinations of phospholipids and semifluorinated alkanes. Direct experimental evidence of the location of the semifluorinated alkane within the bilayer,Langmuir,19(12) : 4889-4894 link

Courrier, H.M.; Vandamme, T.F.; Krafft, M.P.; Nakamura, S.; Shibata, O. (2003), Mixed monolayers made from dipalmitoyl phosphatidylcholine and a fluorinated amphiphile,Colloids And Surfaces A-Physicochemical And Engineering Aspects,215(1-3) : 33-41 link

Giulieri, F.; Krafft, M.P. (2003), Tubular microstructures made from nonchiral single-chain fluorinated amphiphiles: Impact of the structure of the hydrophobic chain on the rolling-up of bilayer membrane,Journal Of Colloid And Interface Science,258(2) : 335-344 link

Courrier, H.M.; Krafft, M.P.; Butz, N.; Porte, C.; Frossard, N.; Remy-Kristensen, A.; Mely, Y.; Pons, F.; Vandamme, T.F. (2003), Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate,Biomaterials,24(4) : 689-696 link


Maaloum, M.; Muller, P.; Krafft, M.P. (2002), Monodisperse surface micelles of nonpolar amphiphiles in Langmuir monolayers,Angewandte Chemie-International Edition,41(22) : 4331-43343.0.CO;2-J> link

Butz, N.; Porte, C.; Courrier, H.; Krafft, M.P.; Vandamme, T.F. (2002), Reverse water-in-fluorocarbon emulsions for use in pressurized metered-dose inhalers containing hydrofluoroalkane propellants,International Journal Of Pharmaceutics,238(1-2) : 257-269 link

Ferro, Y.; Krafft, M.P. (2002), Incorporation of semi-fluorinated alkanes in the bilayer of small unilamellar vesicles of phosphatidylserine: impact on fusion kinetics,Biochimica Et Biophysica Acta-Molecular And Cell Biology Of Lipids,1581(1-2) : 11-20 link


Krafft, M.P.; Giulieri, F.; Fontaine, P.; Goldmann, M. (2001), Reversible stepwise formation of mono- and bilayers of a fluorocarbon/hydrocarbon diblock on top of a phospholipid Langmuir monolayer. A case of vertical phase separation,Langmuir,17(21) : 6577-6584 link

Mathurin, J.C.; de Ceaurriz, J.; Audran, M.; Krafft, M.P. (2001), Detection of perfluorocarbons in blood by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry,Biomedical Chromatography,15(7) : 443-451 link

Brubach, J.B.; Mermet, A.; Filabozzi, A.; Gerschel, A.; Lairez, D.; Krafft, M.P.; Roy, P. (2001), Dependence of water dynamics upon confinement size,Journal Of Physical Chemistry B,105(2) : 430-435 link

DeRoover, A.; Krafft, M.P.; Deby-Dupont, G.; Riess, J.; Jacquet, N.; Lamy, M.; Meurisse, M.; D’Silva, M. (2001), Seventy-two hours hypothermic intestinal preservation study using a new perfluorocarbon emulsion,Artificial Cells Blood Substitutes And Immobilization Biotechnology,29(3) : 225-234 link

Krafft, M.P. (2001), Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research,Advanced Drug Delivery Reviews,47(2-3) : 209-228 link

Krafft, M.P.; Schieldknecht, L.; Marie, P.; Giulieri, F.; Schmutz, M.; Poulain, N.; Nakache, E. (2001), Fluorinated vesicles allow intrabilayer polymerization of a hydrophobic monomer, yielding polymerized microcapsules,Langmuir,17(9) : 2872-2877 link


Shibata, O.; Krafft, M.P. (2000), Mixed Langmuir monolayers made from single-chain perfluoroalkylated amphiphiles,Langmuir,16(26) : 10281-10286 link

Audran, M.; Krafft, M.P.; De Ceaurriz, J.; Maturin, J.C.; Sicart, M.T.; Marion, B.; Bougard, G.; Bressolle, F. (2000), Determination of perfluorodecalin and perfluoro-N-methylcyclohexylpiperidine in rat blood by gas chromatography-mass spectrometry,Journal Of Chromatography B-Analytical Technologies In The Biomedical And Life Sciences,745(2) : 333-343 link

Wang, S.P.; Lunn, R.; Krafft, M.P.; Leblanc, R.M. (2000), One and a half layers?: Mixed Langmuir monolayer of 10,12-pentacosadiynoic acid and a semifluorinated tetracosane,Langmuir,16(6) : 2882-2886 link