Institut Charles Sadron
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- Delphine Chan-Seng
Delphine Chan-Seng
Delphine Chan-Seng received a
B.Sc. degree in chemistry (2000) and a M.Sc. degree in Polymer Sciences (2002)
from the University of Bordeaux (France). During her MSc, she spent 5 months
working in the Macromolecular Chemistry II laboratory (University of Bayreuth,
Germany) on the synthesis of hyperbranched polymers grafted on silica
nanoparticles under the supervision of Axel H. E. Müller and Hideharu Mori, and 7
months at the Laboratoire de Chimie des Polymères Organiques (University of
Bordeaux, France) under the supervision of Henri Cramail and Eric Cloutet on
the synthesis of polyurethane particles in dispersed medium. She earned her
Ph.D. degree in Polymer Chemistry (2007) from the University of Toronto
(Canada) working under the direction of Michael K. Georges, where her thesis
work dealt with controlled radical polymerization focusing on atom transfer
radical polymerization under seeded emulsion conditions and the investigation
of acrylates polymerization under nitroxide-mediated polymerization conditions.
She then conducted postdoctoral research in the group of Todd Emrick at the
University of Massachusetts at Amherst, where she focused on the synthesis of
polymers for targeted applications, such as the synthesis of aliphatic
polyesters and their post-polymerization functionalization used as coatings for
drug-elution cardiovascular stents, and the synthesis of peptide-based comb
polymers used as non-viral vectors for gene therapy. In 2011, she joined the
Institut Charles Sadron as a CNRS researcher.
ORCID profile Researchgate profile
CURRENT RESEARCH
We are interested in developing
polymers based on synthetic and natural building blocks combining organic
chemistry, solid-phase peptide synthesis and polymer chemistry to further
modulate the composition, topology and functionality of polymers and thus
promote specific intrinsic properties to these polymers. Amino
acid- and peptide-based polymers are aimed to find applications in biomedicine (e.g. delivery of small drugs, theranostics, gene
therapy, cell adhesion, materials with antimicrobial activities), while the
development of novel compatibilizers is targeted for composite materials and polymer blends.
Research interest keywords: polymer synthesis, macromolecular
engineering, post-polymerization modification, solid-phase synthesis, polymers for targeted applications




PUBLICATIONS
2022
Razzaq, W.; Serra, C.A.; Jacomine, L.; Chan-Seng, D. (2022), Microfluidic elaboration of polymer microfibers from miscible phases: Effect of operating and material parameters on fiber diameter,
Journal of the Taiwan Institute of Chemical Engineers,132() : 104215
linkRazzaq, W.; Serra, C.; Chan-Seng, D. (2022), Production of Janus/Hecate microfibers by microfluidic photopolymerization and evaluation of their potential in dye removal,
Chemical Communications,58(29) : 4619-4622
linkRazzaq, W.; Serra, C.A.; Chan-Seng, D. (2022), Microfluidic Janus fibers with dual thermoresponsive behavior for thermoactuation,
European Polymer Journal,174() :
link2021
Le Guen, C.; Dussouillez, C.; Kichler, A.; Chan-Seng, D. (2021), Insertion of hydrophobic spacers on dodecalysines as potential transfection enhancers,
European Polymer Journal,157() :
linkKavand, A.; Serra, C.A.; Blanck, C.; Lenertz, M.; Anton, N.; Vandamme, T.F.; Mely, Y.; Przybilla, F.; Chan-Seng, D. (2021), Controlled Synthesis of NaYF4:Yb,Er Upconversion Nanocrystals as Potential Probe for Bioimaging: A Focus on Heat Treatment,
Acs Applied Nano Materials,4(5) : 5319-5329
linkLouwsma, J.; Carvalho, A.; Lutz, J.-F.; Joly, S.; Chan-Seng, D. (2021), Adsorption of phenylalanine-rich sequence-defined oligomers onto Kevlar fibers for fiber-reinforced polyolefin composite materials,
Polymer,217() :
linkFigueiredo, M.L.; Letteri, R.; Chan-Seng, D.; Kumar, S.; Rivera-Cruz, C.M.; Emrick, T.S. (2021), Reengineering Tumor Microenvironment with Sequential Interleukin Delivery,
Bioengineering-Basel,8(7) :
link2020
Kavand, A.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D. (2020), Synthesis and functionalization of hyperbranched polymers for targeted drug delivery,
Journal Of Controlled Release,321() : 285-311
linkZydziak, N.; Iqbal, M.H.; Chaumont, A.; Combes, A.; Wasielewski, E.; Legros, M.; Jierry, L.; Lavalle, P.; Boulmedais, F.; Chan-Seng, D. (2020), Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains,
European Polymer Journal,125() :
linkFigueiredo, M.L.; Figueiredo Neto, M.; Salameh, J.W.; Decker, R.E.; Letteri, R.; Chan-Seng, D.; Emrick, T. (2020), Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo,
Molecular Therapy-Methods & Clinical Development,17() : 739-751
linkKavand, A.; Blanck, C.; Przybilla, F.; Mely, Y.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D. (2020), Investigating the growth of hyperbranched polymers by self-condensing vinyl RAFT copolymerization from the surface of upconversion nanoparticles,
Polymer Chemistry,11(26) : 4313-4325
linkDing, S.; Mustafa, B.; Anton, N.; Serra, C.A.; Chan-Seng, D.; Vandamme, T.F. (2020), Production of lipophilic nanogels by spontaneous emulsification,
International Journal Of Pharmaceutics,585() :
linkKavand, A.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D. (2020), Tuning polymers grafted on upconversion nanoparticles for the delivery of 5-fluorouracil,
European Polymer Journal,137() :
link2018
Chan-Seng, D.; Louwsma, J.; Lutz, J.-F.; Joly, S. (2018), Synthesis of Macromolecules Containing Phenylalanine and Aliphatic Building Blocks,
Macromolecular Rapid Communications,39(8) :
link2016
Fiers, G.; Chouikhi, D.; Oswald, L.; Al Ouahabi, A.; Chan-Seng, D.; Charles, L.; Lutz, J.-F. (2016), Orthogonal Synthesis of Xeno Nucleic Acids,
Chemistry-A European Journal,22(50) : 17945-17948
linkGhobadi, A.F.; Letteri, R.; Parelkar, S.S.; Zhao, Y.; Chan-Seng, D.; Emrick, T.; Jayaraman, A. (2016), Dispersing Zwitterions into Comb Polymers for Nonviral Transfection: Experiments and Molecular Simulation,
Biomacromolecules,17(2) : 546-557
link2015
Oswald, L.; Trinh, T.T.; Chan-Seng, D.; Lutz, J.-F. (2015), Debromination of ATRP-made Wang soluble polymer supports,
Polymer,72() : 341-347
linkTrinh, T.T.; Oswald, L.; Chan-Seng, D.; Charles, L.; Lutz, J.-F. (2015), Preparation of Information-Containing Macromolecules by Ligation of Dyad-Encoded Oligomers,
Chemistry-A European Journal,21(34) : 11961-11965
linkNeto, M.F.; Letteri, R.; Chan-Seng, D.; Emrick, T.; Figueiredo, M.L. (2015), Sonodelivery Facilitates Sustained Luciferase Expression from an Episomal Vector in Skeletal Muscle,
Materials,8(7) : 4608-4617
link2014
Parelkar, S.S.; Letteri, R.; Chan-Seng, D.; Zolochevska, O.; Ellis, J.; Figueiredo, M.; Emrick, T. (2014), Polymer-Peptide Delivery Platforms: Effect of Oligopeptide Orientation on Polymer-Based DNA Delivery,
Biomacromolecules,15(4) : 1328-1336
linkChan-Seng, D.; Lutz, J.-F. (2014), Primary Structure Control of Oligomers Based on Natural and Synthetic Building Blocks,
Acs Macro Letters,3(3) : 291-294
linkTrinh, T.T.; Oswald, L.; Chan-Seng, D.; Lutz, J.-F. (2014), Synthesis of Molecularly Encoded Oligomers Using a Chemoselective “ AB plus CD†Iterative Approach,
Macromolecular Rapid Communications,35(2, Si) : 141-145
link2013
Han, D.; Letteri, R.; Chan-Seng, D.; Emrick, T.; Tu, H. (2013), Examination of zwitterionic polymers and gels subjected to mechanical constraints,
Polymer,54(12) : 2887-2894
link2012
Srichan, S.; Chan-Seng, D.; Lutz, J.-F. (2012), Influence of Strong Electron-Donor Monomers in Sequence-Controlled Polymerizations,
Acs Macro Letters,1(5) : 589-592
linkChan-Seng, D.; Zamfir, M.; Lutz, J.-F. (2012), Polymer-Chain Encoding: Synthesis of Highly Complex Monomer Sequence Patterns by Using Automated Protocols,
Angewandte Chemie-International Edition,51(49) : 12254-12257
link