Institut Charles Sadron Membre
Delphine Chan-Seng
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- Equipe : IRIS
Delphine Chan-Seng received a B.Sc. degree in chemistry (2000) and a M.Sc. degree in Polymer Sciences (2002) from the University of Bordeaux (France). During her MSc, she spent 5 months working in the Macromolecular Chemistry II laboratory (University of Bayreuth, Germany) on the synthesis of hyperbranched polymers grafted on silica nanoparticles under the supervision of Axel H. E. Müller and Hideharu Mori, and 7 months at the Laboratoire de Chimie des Polymères Organiques (University of Bordeaux, France) under the supervision of Henri Cramail and Eric Cloutet on the synthesis of polyurethane particles in dispersed medium. She earned her Ph.D. degree in Polymer Chemistry (2007) from the University of Toronto (Canada) working under the direction of Michael K. Georges, where her thesis work dealt with controlled radical polymerization focusing on atom transfer radical polymerization under seeded emulsion conditions and the investigation of acrylates polymerization under nitroxide-mediated polymerization conditions. She then conducted postdoctoral research in the group of Todd Emrick at the University of Massachusetts at Amherst, where she focused on the synthesis of polymers for targeted applications, such as the synthesis of aliphatic polyesters and their post-polymerization functionalization used as coatings for drug-elution cardiovascular stents, and the synthesis of peptide-based comb polymers used as non-viral vectors for gene therapy. In 2011, she joined the Institut Charles Sadron as a CNRS researcher.
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CURRENT RESEARCH
We are interested in developing polymers based on synthetic and natural building blocks combining organic chemistry, solid-phase peptide synthesis and polymer chemistry to further modulate the composition, topology and functionality of polymers and thus promote specific intrinsic properties to these polymers. Amino acid- and peptide-based polymers are aimed to find applications in biomedicine (e.g. delivery of small drugs, theranostics, gene therapy, cell adhesion, materials with antimicrobial activities), while the development of novel compatibilizers is targeted for composite materials and polymer blends.
Research interest keywords: polymer synthesis, macromolecular
engineering, post-polymerization modification, solid-phase synthesis, polymers for targeted applications
Publications
2025
Journal articles
- titre
- Experimental and Computational Study of Injectable Iron(III)/Ultrashort Peptide Hydrogels: A Candidate for Ferroptosis‐Induced Treatment of Bacterial Infections
- auteur
- Capucine Loth, Florent Barbault, Cécile Guégan, Flora Lemaire, Christophe Contal, Alain Carvalho, Sophie Hellé, Marie Champion, Halima Kerdjoudj, Delphine Chan-Seng, Lydie Ploux, Fouzia Boulmedais
- article
- Small Science, In press, ⟨10.1002/smsc.202400618⟩
- Resume_court
- Injectable hydrogels are promising candidates as local drug delivery platforms for the treatment of .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1002/smsc.202400618
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2024
Journal articles
- titre
- Simultaneous photo-induced polymerization and surface modification by microfluidic spinning to produce functionalized polymer microfibers: the effect of their surface modification on cell adhesion
- auteur
- Wasif Razzaq, Christophe A Serra, Candice Dussouillez, Naji Kharouf, Irene Andrea Acuña Mejía, Antoine Kichler, Delphine Chan-Seng
- article
- RSC Applied Polymers, 2024, 2 (1), pp.62-70. ⟨10.1039/d3lp00032j⟩
- Resume_court
- A capillary-based microfluidic device is used to prepare functionalized polymer microfibers in one-s .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1039/d3lp00032j
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2023
Journal articles
- titre
- Model reactions for the evaluation of poly- and multifunctional molecules as potential interfacial agents for the compatibilization of polyethylene/poly(ethylene-co-vinyl alcohol) blends†
- auteur
- Elisa Gitzhofer, Bertrand Vileno, Michel Bouquey, Delphine Chan-Seng
- article
- Polymer Chemistry, 2023, 14, pp.934-942. ⟨10.1039/d2py01495e⟩
- Resume_court
- In aiming to identify an interfacial agent for polyethylene (PE)/poly(ethylene-co-vinyl alcohol) (EV .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1039/d2py01495e
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2022
Journal articles
- titre
- Microfluidic Janus fibers with dual thermoresponsive behavior for thermoactuation
- auteur
- Wasif Razzaq, Christophe A Serra, Delphine Chan-Seng
- article
- European Polymer Journal, 2022, 174, pp.111321. ⟨10.1016/j.eurpolymj.2022.111321⟩
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- Thermoresponsive bilayer hydrogels have gained attention due to their fast response time and excelle .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.eurpolymj.2022.111321
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- titre
- Production of Janus/Hecate microfibers by microfluidic photopolymerization and evaluation of their potential in dyes removal
- auteur
- Wasif Razzaq, Christophe Serra, Delphine Chan-Seng
- article
- Chemical Communications, 2022, 58 (29), pp.4619-4622. ⟨10.1039/D2CC00214K⟩
- Resume_court
- The production of Janus/Hecate polymer microfibers with well-defined interfaces by microfluidic phot .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1039/D2CC00214K
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2021
Journal articles
- titre
- Controlled synthesis of NaYF 4 :Yb,Er upconversion nanocrystals as potential probe for bioimaging: A focus on heat treatment
- auteur
- Alireza Kavand, Christophe A Serra, Christian Blanck, Marc Lenertz, Nicolas Anton, Thierry F Vandamme, Yves Mély, Frédéric Przybilla, Delphine Chan-Seng
- article
- ACS Applied Nano Materials, 2021, 4 (5), pp.5319-5329. ⟨10.1021/acsanm.1c00664⟩
- Resume_court
- Upconversion nanoparticles are a promising class of materials for bioimaging. Their attractive optic .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1021/acsanm.1c00664
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- titre
- Insertion of hydrophobic spacers on dodecalysines as potential transfection enhancers
- auteur
- Clothilde Le Guen, Candice Dussouillez, Antoine Kichler, Delphine Chan-Seng
- article
- European Polymer Journal, 2021, 157, pp.110654. ⟨10.1016/j.eurpolymj.2021.110654⟩
- Resume_court
- The use of cationic polymers in gene therapy aims at improving the circulation, protection and deliv .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.eurpolymj.2021.110654
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- titre
- Adsorption of phenylalanine-rich sequence-defined oligomers onto Kevlar fibers for fiber-reinforced polyolefin composite materials
- auteur
- Jeroen Louwsma, Alain Carvalho, Jean-François Lutz, Stéphane Joly, Delphine Chan-Seng
- article
- Polymer, 2021, 217, pp.123465. ⟨10.1016/j.polymer.2021.123465⟩
- Resume_court
- Oligomers comprising four or sixteen phenylalanine residues with regularly intercalated aliphatic ch .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.polymer.2021.123465
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2020
Journal articles
- titre
- Tuning polymers grafted on upconversion nanoparticles for the delivery of 5-fluorouracil
- auteur
- Alireza Kavand, Nicolas Anton, Thierry Vandamme, Christophe Serra, Delphine Chan-Seng
- article
- European Polymer Journal, 2020, 137, pp.109935. ⟨10.1016/j.eurpolymj.2020.109935⟩
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- Efficient and safe delivery of anticancer drugs such as 5-fluorouracil (5-FU) is still a challenge i .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.eurpolymj.2020.109935
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- titre
- Investigating the growth of hyperbranched polymers by self-condensing vinyl RAFT copolymerization from the surface of upconversion nanoparticles
- auteur
- Alireza Kavand, Christian Blanck, Frédéric Przybilla, Yves Mély, Nicolas Anton, Thierry Vandamme, Christophe Serra, Delphine Chan-Seng
- article
- Polymer Chemistry, 2020, 11 (26), pp.4313-4325. ⟨10.1039/d0py00452a⟩
- Resume_court
- Hyperbranched poly(N-(2-hydroxypropyl) methacrylamide)s grafted on upconversion nanoparticles (UCNPs .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1039/d0py00452a
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- titre
- Production of lipophilic nanogels by spontaneous emulsification
- auteur
- Shukai Ding, Bilal Mustafa, Nicolas Anton, Christophe Serra, Delphine Chan-Seng, Thierry Vandamme
- article
- International Journal of Pharmaceutics, 2020, 585, pp.119481. ⟨10.1016/j.ijpharm.2020.119481⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.ijpharm.2020.119481
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- titre
- Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo
- auteur
- Marxa L Figueiredo, Manoel Eulálio Neto, Janelle Wes Salameh, Richard E Decker, Rachel Letteri, Delphine Chan-Seng, Todd Emrick
- article
- Molecular Therapy - Methods and Clinical Development, 2020, 17, pp.739-751. ⟨10.1016/j.omtm.2020.03.022⟩
- Resume_court
- We have examined the role of a novel targeted cytokine, inter-leukin-27 (IL-27), modified at the C t .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.omtm.2020.03.022
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- titre
- SYNTHESIS AND FUNCTIONALIZATION OF HYPERBRANCHED POLYMERS FOR TARGETED DRUG DELIVERY
- auteur
- Alireza Kavand, Nicolas Anton, Thierry Vandamme, Christophe Serra, Delphine Chan-Seng
- article
- Journal of Controlled Release, 2020, 321, pp.285-311. ⟨10.1016/j.jconrel.2020.02.019⟩
- Resume_court
- Hyperbranched polymers (HBPs) have found use in a wide range of applications, such as optical, elect .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.jconrel.2020.02.019
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- titre
- Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains
- auteur
- Nicolas Zydziak, Muhammad Haseeb Iqbal, Alain Chaumont, Antoine Combes, Emeric Wasielewski, Mélanie Legros, Loïc Jierry, Philippe Lavalle, Fouzia Boulmedais, Delphine Chan-Seng
- article
- European Polymer Journal, 2020, 125, pp.109528. ⟨10.1016/j.eurpolymj.2020.109528⟩
- Resume_court
- Thermoresponsive polymers, undergoing a reversible chemical or physical change using temperature as .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.eurpolymj.2020.109528
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2018
Journal articles
- titre
- Synthesis of Macromolecules Containing Phenylalanine and Aliphatic Building Blocks
- auteur
- Delphine Chan-Seng, Jeroen Louwsma, Jean-François Lutz, Stéphane Joly
- article
- Macromolecular Rapid Communications, 2018, 39 (8), pp.1700764. ⟨10.1002/marc.201700764⟩
- Resume_court
- Aiming at developing efficient interfacial agents for fiber‐reinforced composite materials, macrom .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1002/marc.201700764
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2016
Journal articles
- titre
- Orthogonal Synthesis of Xeno Nucleic Acids
- auteur
- Guillaume Fiers, Dalila Chouikhi, Laurence Oswald, Abdelaziz Al Ouahabi, Delphine Chan-Seng, Laurence Charles, Jean-Francois Lutz
- article
- Chemistry - A European Journal, 2016, 22 (50), pp.17945-17948. ⟨10.1002/chem.201604386⟩
- Resume_court
- Sequence-defined peptide triazole nucleic acids (PTzNA) were synthesized by means of a solid-phase o .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1002/chem.201604386
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- titre
- Dispersing Zwitterions into Comb Polymers for Nonviral Transfection: Experiments and Molecular Simulation
- auteur
- Ahmadreza F. Ghobadi, Rachel Letteri, Sangram S. Parelkar, Yue Zhao, Delphine Chan-Seng, Todd Emrick, Arthi Jayaraman
- article
- Biomacromolecules, 2016, 17 (2), pp.546-557. ⟨10.1021/acs.biomac.5b01462⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1021/acs.biomac.5b01462
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2015
Journal articles
- titre
- Debromination of ATRP-made Wang soluble polymer supports
- auteur
- Laurence Oswald, Thanh Tam Trinh, Delphine Chan-Seng, Jean-François Lutz
- article
- Polymer, 2015, 72, pp.341-347. ⟨10.1016/j.polymer.2015.02.057⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.polymer.2015.02.057
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- titre
- Preparation of Information-Containing Macromolecules by Ligation of Dyad-Encoded Oligomers
- auteur
- Thanh Tam Trinh, Laurence Oswald, Delphine Chan-Seng, Laurence Charles, Jean-François Lutz
- article
- Chemistry - A European Journal, 2015, 21 (34), pp.11961--11965. ⟨10.1002/chem.201502414⟩
- Resume_court
- A simplified strategy for preparing non-natural information-containing polymers is reported. The con .....
- typdoc
- Journal articles
- DOI
- DOI : 10.1002/chem.201502414
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- titre
- Sonodelivery Facilitates Sustained Luciferase Expression from an Episomal Vector in Skeletal Muscle
- auteur
- Manoel Neto, Rachel Letteri, Delphine Chan-Seng, Todd Emrick, Marxa Figueiredo
- article
- Materials, 2015, 8 (7), pp.4608-4617. ⟨10.3390/ma8074608⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.3390/ma8074608
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2014
Journal articles
- titre
- Polymer–Peptide Delivery Platforms: Effect of Oligopeptide Orientation on Polymer-Based DNA Delivery
- auteur
- Sangram S. Parelkar, Rachel Letteri, Delphine Chan-Seng, Olga Zolochevska, Jayne Ellis, Marxa Figueiredo, Todd Emrick
- article
- Biomacromolecules, 2014, 15 (4), pp.1328-1336. ⟨10.1021/bm401878p⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1021/bm401878p
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- titre
- Primary Structure Control of Oligomers Based on Natural and Synthetic Building Blocks
- auteur
- Delphine Chan-Seng, Jean-François Lutz
- article
- ACS Macro Letters, 2014, 3 (3), pp.291-294. ⟨10.1021/mz5000575⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1021/mz5000575
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- titre
- Synthesis of Molecularly Encoded Oligomers Using a Chemoselective “AB + CD” Iterative Approach
- auteur
- Thanh Tam Trinh, Laurence Oswald, Delphine Chan-Seng, Jean-François Lutz
- article
- Macromolecular Rapid Communications, 2014, 35 (2), pp.141-145. ⟨10.1002/marc.201300774⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1002/marc.201300774
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Book sections
- titre
- Solid-Phase Synthesis as a Tool for the Preparation of Sequence-Defined Oligomers Based on Natural Amino Acids and Synthetic Building Blocks
- auteur
- Delphine Chan-Seng, Jean-François Lutz
- article
- Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties, ACS Symposium SeriesVol. 1170, pp.103-116, 2014, ⟨10.1021/bk-2014-1170.ch007⟩
- typdoc
- Book sections
- DOI
- DOI : 10.1021/bk-2014-1170.ch007
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2013
Journal articles
- titre
- Interleukin-27 Gene Delivery for Modifying Malignant Interactions Between Prostate Tumor and Bone
- auteur
- Olga Zolochevska, Jayne Ellis, Sangram Parelkar, Delphine Chan-Seng, Todd Emrick, Jingna Wei, Igor Patrikeev, Massoud Motamedi, Marxa L. Figueiredo
- article
- Human Gene Therapy, 2013, 24 (12), pp.970-981. ⟨10.1089/hum.2013.091⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1089/hum.2013.091
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- titre
- Examination of zwitterionic polymers and gels subjected to mechanical constraints
- auteur
- Dingzhi Han, Rachel Letteri, Delphine Chan-Seng, Todd Emrick, Huilin Tu
- article
- Polymer, 2013, 54 (12), pp.2887-2894. ⟨10.1016/j.polymer.2013.04.003⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1016/j.polymer.2013.04.003
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- titre
- Microstructure Control: An Underestimated Parameter in Recent Polymer Design
- auteur
- Nezha Badi, Delphine Chan-Seng, Jean-François Lutz
- article
- Macromolecular Chemistry and Physics, 2013, 214 (2), pp.135-142. ⟨10.1002/macp.201200475⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1002/macp.201200475
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Book sections
- titre
- Functional Polymers with Controlled Microstructure Based on Styrene and N -Substituted Maleimides
- auteur
- Delphine Chan-Seng, Mirela Zamfir, Jean-François Lutz
- article
- Functional Polymers by Post-Polymerization Modification, Wiley-VCH Verlag GmbH & Co. KGaA, pp.173-192, 2013, ⟨10.1002/9783527655427.ch7⟩
- typdoc
- Book sections
- DOI
- DOI : 10.1002/9783527655427.ch7
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2012
Journal articles
- titre
- Polymer-Chain Encoding: Synthesis of Highly Complex Monomer Sequence Patterns by Using Automated Protocols
- auteur
- Delphine Chan-Seng, Mirela Zamfir, Jean-François Lutz
- article
- Angewandte Chemie International Edition, 2012, 51 (49), pp.12254-12257. ⟨10.1002/anie.201206371⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1002/anie.201206371
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- titre
- Influence of Strong Electron-Donor Monomers in Sequence-Controlled Polymerizations
- auteur
- Sansanee Srichan, Delphine Chan-Seng, Jean-François Lutz
- article
- ACS Macro Letters, 2012, 1 (5), pp.589-592. ⟨10.1021/mz3001513⟩
- typdoc
- Journal articles
- DOI
- DOI : 10.1021/mz3001513
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